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71 Treatment with TMS Improves Aspects of Attention in Depression: A Pilot Study
- Nicole C Walker, Nathan Ramirez, Laurie Chin, Sonia S Rehman, Stephanie C Gee, Kathleen Hodges, Leanne M Williams, Robert Hickson, L. Chauncey Green, Talaya Patton, Hanaa Aldasouqi, Noah S Philip, F. Andrew Kozel, Jerome A Yesavage, Michelle R Madore
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- Journal:
- Journal of the International Neuropsychological Society / Volume 29 / Issue s1 / November 2023
- Published online by Cambridge University Press:
- 21 December 2023, pp. 476-477
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Objective:
Repetitive transcranial magnetic stimulation (TMS) is an evidenced based treatment for adults with treatment resistant depression (TRD). The standard clinical protocol for TMS is to stimulate the left dorsolateral prefrontal cortex (DLPFC). Although the DLPFC is a defining region in the cognitive control network of the brain and implicated in executive functions such as attention and working memory, we lack knowledge about whether TMS improves cognitive function independent of depression symptoms. This exploratory analysis sought to address this gap in knowledge by assessing changes in attention before and after completion of a standard treatment with TMS in Veterans with TRD.
Participants and Methods:Participants consisted of 7 Veterans (14.3% female; age M = 46.14, SD = 7.15; years education M = 16.86, SD = 3.02) who completed a full 30-session course of TMS treatment and had significant depressive symptoms at baseline (Patient Health Questionnaire-9; PHQ-9 score >5). Participants were given neurocognitive assessments measuring aspects of attention [Wechsler Adult Intelligence Scale 4th Edition (WAIS-IV) subtests: Digits Forward, Digits Backward, and Number Sequencing) at baseline and again after completion of TMS treatment. The relationship between pre and post scores were examined using paired-samples t-test for continuous variables and a linear regression to covary for depression and posttraumatic stress disorder (PTSD), which is often comorbid with depression in Veteran populations.
Results:There was a significant improvement in Digit Span Forward (p=.01, d=-.53), but not Digit Span Backward (p=.06) and Number Sequencing (p=.54) post-TMS treatment. Depression severity was not a significant predictor of performance on Digit Span Forward (f(1,5)=.29, p=.61) after TMS treatment. PTSD severity was also not a significant predictor of performance on Digit Span Forward (f(1,5)=1.31, p=.32).
Conclusions:Findings suggested that a standard course of TMS improves less demanding measures of working memory after a full course of TMS, but possibly not the more demanding aspects of working memory. This improvement in cognitive function was independent of improvements in depression and PTSD symptoms. Further investigation in a larger sample and with direct neuroimaging measures of cognitive function is warranted.
Ethofumesate-resistant annual bluegrass (Poa annua) in grass seed production systems
- Vera Vukovic, Clint M. Mattox, Alec R. Kowalewski, Brandon C. McNally, Cale A. Bigelow, Stephen L. Meyers, James T. Brosnan, Aaron J. Patton
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- Journal:
- Weed Technology / Volume 37 / Issue 6 / December 2023
- Published online by Cambridge University Press:
- 13 October 2023, pp. 628-636
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The prolific seed production and polyploidy of annual bluegrass allow for the rapid development of herbicide resistance. Ethofumesate-resistant annual bluegrass plants were identified in the 1990s in grass seed production in Oregon, but their prevalence and distribution are not well documented. Therefore a dose–response experiment was initiated to determine the potential level of ethofumesate resistance in seed production systems. Seeds from 55 annual bluegrass populations were obtained from three sources: seed production fields (31 populations), the seed cleaning process (6 populations), and seed testing lots prior to retail distribution (18 populations). Additionally, two populations, one with known ethofumesate resistance and one with known susceptibility, were identified in preliminary testing and used as controls in this experiment. Seed from each collected population was increased. Individual seedlings were then transplanted into separate cone-tainers, grown to a size of 2 to 3 tillers in the greenhouse, and then sprayed using a compressed air track spray chamber with 10 doses of ethofumesate at 0, 0.56, 1.1, 2.8, 5.6, 8.4, 11.2, 16.8, 22.4, and 44.8 kg ai ha−1, with 0.84 to 2.2 kg ha−1 as the label application rate for perennial ryegrass. The resistant to susceptible ratio of populations across all sources ranged from 0.5 to 5.5. The most resistant populations found in production fields, seed cleaning, and seed testing lots had the effective dose necessary to kill 50% of the population (ED50) of 12.1, 9.4, and 13.1 kg ha−1, respectively. Furthermore, 68% of the populations found in production fields had ED50 higher than 6 kg ha−1, indicating common annual bluegrass resistance in grass seed production. As such, growers should implement integrated weed management strategies, as herbicides alone will likely be ineffective at controlling annual bluegrass.
Reconstructing Holocene fire records using dune footslope deposits at the Cooloola Sand Mass, Australia
- Nicholas R. Patton, James Shulmeister, Quan Hua, Peter Almond, Tammy M. Rittenour, Johanna M. Hanson, Aloysius Grealy, Jack Gilroy, Daniel Ellerton
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- Journal:
- Quaternary Research / Volume 115 / September 2023
- Published online by Cambridge University Press:
- 11 May 2023, pp. 67-89
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In this study, we assess charcoal records from eolian deposits within the Cooloola Sand Mass, a subtropical coastal dune system in eastern Australia, to determine whether they can be used as a proxy for Holocene fire history. We excavate four profiles in depositional wedges at the base of dune slipfaces (footslope deposits) and calculate charcoal concentrations for three size classes (180–250 μm, 250–355 μm, and 355 μm–2 mm) at predetermined depth intervals. Age–depth models are constructed for each profile using radiocarbon measurements (n = 46) and basal optically stimulated luminescence ages (n = 4). All records appear intact with little evidence of postdepositional mixing as demonstrated by minimal age reversals and consistent trends in charcoal concentration and accumulation rates (CHAR) among size classes. Combining all four records, we generate a ca. 7 cal ka BP terrestrial fire history that depicts distinct peaks representing periods of increased local fire activity at <0.3, 1.1–0.4, 2.2–1.6, 3.4–2.6, and 6.7–5.3 cal ka BP. Our findings parallel regional records and highlight the utility of dune footslopes as ecological and sedimentary archives. As dune fields are much more common than wetlands and lakes in semiarid and arid areas, these deposits have the potential to increase the spatial resolution of fire records globally.
Number Needed to Treat and Number Needed to Harm From Two Phase 3 Studies of Sublingual Dexmedetomidine for Treating Acute Agitation in Patients With Schizophrenia and Bipolar Disorder
- Citrome L, Risinger R, Rajachandran L, Patton E, Robison H
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- Journal:
- CNS Spectrums / Volume 28 / Issue 2 / April 2023
- Published online by Cambridge University Press:
- 14 April 2023, p. 226
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Background
Episodes of acute agitation can occur in individuals who suffer from schizophrenia or bipolar disorder and these can be a significant challenge for patients and for those who provide care to them. Sublingual dexmedetomidine is a selective alpha2-adrenergic receptor agonist that was recently approved by the US Food and Drug Administration for the treatment of agitation in adults with schizophrenia or bipolar disorder. The sublingual form of dexmedetomidine does not undergo first-pass hepatic metabolism, thus resulting in greater absorption than when ingested. In two Phase 3 studies of adults with schizophrenia or bipolar disorder, sublingual dexmedetomidine significantly reduced acute agitation at 2 hours, as measured by the five-item Positive and Negative Syndrome Scale-Excited Component (PEC). When initially appraising the potential utility of a new medication, number needed to treat (NNT) and needed to harm (NNH) can be helpful to assess the size of the treatment effect and, hence, clinical relevance.
ObjectiveCalculation of NNT and NNH through post hoc analysis of Phase 3 data.
MethodsPost hoc analysis of data were performed on data from two double-blind, randomized, placebo-controlled studies of sublingual dexmedetomidine in adults with schizophrenia or bipolar disorder experiencing acute agitation. Patients were randomized to a single dose of sublingual dexmedetomidine 180 μg, 120 μg, or placebo. The primary endpoint was mean change from baseline in the PEC total score. A therapeutic response was defined as a ≥40% reduction from baseline in PEC total score at 2 hours. NNT was calculated for PEC response rate for sublingual dexmedetomidine versus placebo. NNH was calculated using the incidence of adverse events for sublingual dexmedetomidine versus placebo. Likelihood to be helped or harmed (LHH) was calculated as the ratio of NNH to NNT.
ResultsNNT (95% CI) was 3 (2, 3) for 180 mcg and 3 (3, 4) for 120 ug in patients with schizophrenia and 3 (2, 3) for 180 mcg and 4 (3, 6) for 120 ug in patients with bipolar disorder. NNH was greater than 10 for all AEs except somnolence, where NNH was 7 (5, 10) for all doses pooled from both studies. LLH values were greater than 1 for efficacy versus applicable tolerability outcomes in all cases.
ConclusionsThis post hoc analysis demonstrated favorable NNT and NNH values for sublingual dexmedetomidine. In all instances therapeutic response was encountered more frequently than any adverse event. These values compare favorably to similar analyses for other approved agents for the treatment of agitation associated with schizophrenia or bipolar disorder, including intramuscular and inhaled formulations.
FundingBioXcel Therapeutics, Inc.
What do non-dietitian health professionals think about giving nutrition advice?
- R. Crawford, N. Patton, K. Murphy
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- Journal:
- Proceedings of the Nutrition Society / Volume 82 / Issue OCE2 / 2023
- Published online by Cambridge University Press:
- 22 March 2023, E83
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Creating a culture that supports food security and health equity at higher education institutions
- Mateja R Savoie-Roskos, Lanae B Hood, Rebecca L Hagedorn-Hatfield, Matthew J Landry, Megan M Patton-López, Rickelle Richards, Jody L Vogelzang, Zubaida Qamar, Kendra OoNorasak, Georgianna Mann
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- Journal:
- Public Health Nutrition / Volume 26 / Issue 3 / March 2023
- Published online by Cambridge University Press:
- 02 November 2022, pp. 503-509
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Food insecurity on college campuses is a major public health problem and has been documented for the last decade. Sufficient food access is a crucial social determinant of health, thus campuses across the country have implemented various programmes, systems and policies to enhance access to food which have included food pantries, campus gardens, farmers’ markets, meal share or voucher programmes, mobile food applications, campus food gleaning, food recovery efforts, meal deliveries and task force/working groups. However, little is understood about how to best address food insecurity and support students who are struggling with basic needs. The impact of food insecurity on students’ academic and social success, in addition to their overall well-being, should be investigated and prioritised at each higher education institution. This is especially true for marginalised students, such as minority or first-generation students, who are at heightened risk for food insecurity. In order to create a culture of health equity, in which most at-risk students are provided resources and opportunities to achieve optimal well-being, higher education institutions must prioritise mitigating food insecurity on the college campus. Higher education institutions could benefit from adopting comprehensive and individualised approaches to promoting food security for marginalised students in order to facilitate equal opportunity for optimal scholastic achievement among students of all socio-demographic backgrounds.
Epidemiology and genomics of a slow outbreak of methicillin-resistant Staphyloccus aureus (MRSA) in a neonatal intensive care unit: Successful chronic decolonization of MRSA-positive healthcare personnel
- Kathleen A. Quan, Mohamad R. A. Sater, Cherry Uy, Robin Clifton-Koeppel, Linda L. Dickey, William Wilson, Pat Patton, Wayne Chang, Pamela Samuelson, Georgia K. Lagoudas, Teri Allen, Lenny Merchant, Rick Gannotta, Cassiana E. Bittencourt, J. C. Soto, Kaye D. Evans, Paul C. Blainey, John Murray, Dawn Shelton, Helen S. Lee, Matthew Zahn, Julia Wolfe, Keith Madey, Jennifer Yim, Shruti K. Gohil, Yonatan H. Grad, Susan S. Huang
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 44 / Issue 4 / April 2023
- Published online by Cambridge University Press:
- 16 June 2022, pp. 589-596
- Print publication:
- April 2023
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Objective:
To describe the genomic analysis and epidemiologic response related to a slow and prolonged methicillin-resistant Staphylococcus aureus (MRSA) outbreak.
Design:Prospective observational study.
Setting:Neonatal intensive care unit (NICU).
Methods:We conducted an epidemiologic investigation of a NICU MRSA outbreak involving serial baby and staff screening to identify opportunities for decolonization. Whole-genome sequencing was performed on MRSA isolates.
Results:A NICU with excellent hand hygiene compliance and longstanding minimal healthcare-associated infections experienced an MRSA outbreak involving 15 babies and 6 healthcare personnel (HCP). In total, 12 cases occurred slowly over a 1-year period (mean, 30.7 days apart) followed by 3 additional cases 7 months later. Multiple progressive infection prevention interventions were implemented, including contact precautions and cohorting of MRSA-positive babies, hand hygiene observers, enhanced environmental cleaning, screening of babies and staff, and decolonization of carriers. Only decolonization of HCP found to be persistent carriers of MRSA was successful in stopping transmission and ending the outbreak. Genomic analyses identified bidirectional transmission between babies and HCP during the outbreak.
Conclusions:In comparison to fast outbreaks, outbreaks that are “slow and sustained” may be more common to units with strong existing infection prevention practices such that a series of breaches have to align to result in a case. We identified a slow outbreak that persisted among staff and babies and was only stopped by identifying and decolonizing persistent MRSA carriage among staff. A repeated decolonization regimen was successful in allowing previously persistent carriers to safely continue work duties.
21083 Perceptions on the Role of Physical Therapy Providers for Falls Prevention: A Qualitative Investigation
- Jennifer L. Vincenzo, Susan Kane Patton, Leanne L. Lefler, Jason R. Falvey, Pearl A. McElfish, Geoffrey Curran, Jeanne Wei
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- Journal:
- Journal of Clinical and Translational Science / Volume 5 / Issue s1 / March 2021
- Published online by Cambridge University Press:
- 30 March 2021, p. 126
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ABSTRACT IMPACT: Being explicit about the prevention of falls throughout an older adults’ episode of care may further help reinforce the role of physical therapy providers in falls prevention and improve dissemination of this knowledge. OBJECTIVES/GOALS: The purpose of this study was to determine older adults’ awareness of and perspectives about the role of physical therapy providers for falls prevention and determine potential barriers and facilitators to utilization of preventive rehabilitation services METHODS/STUDY POPULATION: We used a qualitative descriptive phenomenological approach to emphasize participants’ perceptions and lived experiences. Four focus groups were conducted with 27 community-dwelling older adults (average age = 78 years). Focus groups were recorded, transcribed, condensed, and coded using thematic analysis. RESULTS/ANTICIPATED RESULTS: Surveys indicated 37% of participants experienced a fall in the last year and 26% reported suffering an injury. Four main themes and six subthemes surrounding older adults’ perceptions of physical therapy providers’ roles for falls prevention emerged: (1) Awareness of Falls Prevention (subthemes: I Don’t Think About It, I Am More Careful); (2) Being Able to Get Up from the Floor; (3) Limited Knowledge about the Role of Physical Therapy Providers in Falls Prevention (subtheme: Physical Therapy Services are for After a Fall, Surgery, or for a Specific Problem); and 4). Barriers to Participating in Preventive Physical Therapy Services (subthemes: Perceived Need and Costs, Access Requires a Doctor’s Prescription). DISCUSSION/SIGNIFICANCE OF FINDINGS: Older adults lack awareness about the role of physical therapy services in falls prevention, perceiving services are only to treat a specific problem or after a fall. Physical therapists should be explicit about the role of physical therapy in falls prevention for all older adults undergoing rehabilitation, regardless of the reason.
The time spent in fresh cow pen influences total lactational performance
- F. Hoseyni, D. Zahmatkesh, E. Mahjoubi, M. Hossein Yazdi, R. A. Patton
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- The Journal of Agricultural Science / Volume 158 / Issue 3 / April 2020
- Published online by Cambridge University Press:
- 17 July 2020, pp. 247-253
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This research paper addresses the effect of different grouping strategies of fresh cows on total lactational and reproductive performance. Hundred-sixty multiparous Holstein cows were enrolled in a completely randomized design and assigned to one of following treatments: 21 days in fresh pen with 12.5 kg/day concentrate (C21, n = 60), 10 days in fresh pen with 12.5 kg/day concentrate (C10, n = 50) and 10 days in fresh pen with 10 kg/day concentrate (L10, n = 50). Although there were no differences among treatments within the first 10 days in milk (DIM), C10 and L10 cows tended to produce more milk than C21 from 10 to 21 DIM. In addition, greater milk yield was obtained in C10 and L10 cows during 22–28 DIM and 29–70 DIM. Higher production in early lactation resulted in a tendency for greater milk production for C10 and L10 cows throughout a 305 days lactation. There was no difference in productivity between C10 and L10 groups at any time point. No blood metabolites (Ca, P, non-esterified fatty acids and β-hydroxy butyrate) were affected by treatments. Pregnancy at first, second and third service was 38, 39 and 40%, respectively, which were not influenced by the days in fresh pen or concentrate allowance. Collectively, our results for the first time suggest that fresh cow grouping strategy has a long-term effect on productivity but that adding 2.5 kg/day concentrate has no effect on milk yield in fresh pen.
Threatened efficiency not autonomy: Prescriber perceptions of an established pediatric antimicrobial stewardship program
- Julia E. Szymczak, Eimear Kitt, Molly Hayes, Kathleen Chiotos, Susan E. Coffin, Emily R. Schriver, Ashley M. Patton, Talene A. Metjian, Jeffrey S. Gerber
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 40 / Issue 5 / May 2019
- Published online by Cambridge University Press:
- 28 March 2019, pp. 522-527
- Print publication:
- May 2019
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Background:
Implementing antimicrobial stewardship programs (ASPs) can be challenging due to prescriber resistance. Although barriers to implementing new ASPs have been identified, little is known about how prescribers perceive established programs. This information is critical to promoting the sustainability of ASPs.
Objective:To identify how prescribers perceive an established pediatric inpatient ASP that primarily utilizes prior authorization.
Methods:We conducted a cross-sectional survey administered from February through June 2017 in a large children’s hospital. The survey contained closed- and open-ended questions. Descriptive statistics and thematic content analysis approaches were used to analyze responses.
Results:Of 394 prescribers invited, 160 (41%) responded. Prescribers had an overall favorable impression of the ASP, believing that it improves the quality of care (92.4% agree) and takes their judgment seriously (73.8%). The most common criticism of the ASP was that it threatened efficiency (26.0% agreed). In addition, 68.7% of respondents reported occasionally engaging in workarounds. Analysis of 133 free-text responses revealed that prescribers perceived that interacting with the ASP involved too many phone calls, caused communication breakdowns with the dispensing pharmacy, and led to gaps between approval and dispensing of antibiotics. Reasons given for workarounds included not wanting to change therapy that appears to be working, consultant disagreement with ASP recommendations, and the desire to do everything possible for patients.
Conclusions:Prescribers had a generally favorable opinion of an established ASP but found aspects to be inefficient. They reported engaging in workarounds occasionally for social and emotional reasons. Established ASPs should elicit feedback from frontline prescribers to optimize program impact.
2092 A multicenter study of fecal microbiota transplantation for Clostridium difficile infection in children
- Maribeth R. Nicholson, Erin Alexander, Mark Bartlett, Penny Becker, Zev Davidovics, Elizabeth E. Knackstedt, Michael Docktor, Michael Dole, Grace Felix, Jonathan Gisser, Suchitra Hourigan, Kyle Jensen, Jess Kaplan, Judith Kelsen, Melissa Kennedy, Sahil Khanna, McKenzie Leier, Jeffery Lewis, Ashley Lodarek, Sonia Michail, Paul Mitchell, Maria Oliva‐Hemker, Tiffany Patton, Karen Queliza, Namita Singh, Aliza Solomon, David Suskind, Steven Werlin, Richard Kellermayer, Stacy Kahn
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- Journal:
- Journal of Clinical and Translational Science / Volume 2 / Issue S1 / June 2018
- Published online by Cambridge University Press:
- 21 November 2018, p. 64
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OBJECTIVES/SPECIFIC AIMS: Clostridium difficile infection (CDI) is the most common cause of antibiotic-associated diarrhea and an increasingly common infection in children in both hospital and community settings. Between 20% and 30% of pediatric patients will have a recurrence of symptoms in the days to weeks following an initial infection. Multiple recurrences have been successfully treated with fecal microbiota transplantation (FMT), though the body of evidence in pediatric patients is limited primarily to case reports and case series. The goal of our study was to better understand practices, success, and safety of FMT in children as well as identify risk factors associated with a failed FMT in our pediatric patients. METHODS/STUDY POPULATION: This multicenter retrospective analysis included 373 patients who underwent FMT for CDI between January 1, 2006 and January 1, 2017 from 18 pediatric centers. Demographics, baseline characteristics, FMT practices, C. difficile outcomes, and post-FMT complications were collected through chart abstraction. Successful FMT was defined as no recurrence of CDI within 60 days after FMT. Of the 373 patients in the cohort, 342 had known outcome data at two months post-FMT and were included in the primary analysis evaluating risk factors for recurrence post-FMT. An additional six patients who underwent FMT for refractory CDI were excluded from the primary analysis. Unadjusted analysis was performed using Wilcoxon rank-sum test, Pearson χ2 test, or Fisher exact test where appropriate. Stepwise logistic regression was utilized to determine independent predictors of success. RESULTS/ANTICIPATED RESULTS: The median age of included patients was 10 years (IQR; 3.0, 15.0) and 50% of patients were female. The majority of the cohort was White (89.0%). Comorbidities included 120 patients with inflammatory bowel disease (IBD) and 14 patients who had undergone a solid organ or stem cell transplantation. Of the 336 patients with known outcomes at two months, 272 (81%) had a successful outcome. In the 64 (19%) patients that did have a recurrence, 35 underwent repeat FMT which was successful in 20 of the 35 (57%). The overall success rate of FMT in preventing further episodes of CDI in the cohort with known outcome data was 87%. Unadjusted predictors of a primary FMT response are summarized. Based on stepwise logistic regression modeling, the use of fresh stool, FMT delivery via colonoscopy, the lack of a feeding tube, and a lower number of CDI episodes before undergoing FMT were independently associated with a successful outcome. There were 20 adverse events in the cohort assessed to be related to FMT, 6 of which were felt to be severe. There were no deaths assessed to be related to FMT in the cohort. DISCUSSION/SIGNIFICANCE OF IMPACT: The overall success of FMT in pediatric patients with recurrent or severe CDI is 81% after a single FMT. Children without a feeding tube, who receive an early FMT, FMT with fresh stool, or FMT via colonoscopy are less likely to have a recurrence of CDI in the 2 months following FMT. This is the first large study of FMT for CDI in a pediatric cohort. These findings, if confirmed by additional prospective studies, will support alterations in the practice of FMT in children.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
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15 - Space magnetometry
- from Part II - Applications
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- By B. Patton, University of California, A. W. Brown, Polatomic Inc., R. E. Slocum, Polatomic Inc., E. J. Smith, California Institute of Technology
- Edited by Dmitry Budker, University of California, Berkeley, Derek F. Jackson Kimball, California State University, East Bay
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- Optical Magnetometry
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- 05 May 2013
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- 07 March 2013, pp 285-302
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Summary
Introduction
Magnetometry has been an invaluable tool in all stages of space exploration, from the first ionospheric sounding rockets to the most modern interplanetary probes. Our solar system is fundamentally a magnetically active environment – indeed, one might define the extent of the solar system by its heliopause, as it is the magnetic influence of the Sun which separates us from the interstellar medium. The interactions between the solar wind and the bodies of the solar system are varied and complex, and they have strong implications for the past and future of these bodies. Most importantly, a planet's magnetic field is one of the few characteristics which can be measured from space to yield information about the nature and dynamics of its interior. Recognizing these scientific imperatives, mission designers have included precise magnetometers on nearly all the spacecraft used to explore our solar system; this in turn has driven advances in magnetometer technology over the past fifty years.
Achievements of space magnetometry
Discoveries made by space magnetometers have been among the most profound achievements of space exploration. Rocket-borne magnetometers gave the first definitive evidence of electrical currents in the Earth's ionosphere and their effect on diurnal variations of the geomagnetic field [1]. These data not only shed light on the interaction between the solar wind and the Earth; they also complemented radiation studies which mapped out the Van Allen belts and thus paved the way for manned space flight. Later spacecraft magnetometers advanced dynamo theory by confirming the lack of a planet-scale dipolar field on Venus [2,3] and discovering, to much surprise, a still-active dynamo within Mercury [4].
13 - Remote detection magnetometry
- from Part II - Applications
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- By S. M. Rochester, University of California, J. M. Higbie, Bucknell University, B. Patton, University of California, D. Budker, University of California, R. Holzlöhner, Bucknell University, D. Bonaccini Calia, Laser Systems Department
- Edited by Dmitry Budker, University of California, Berkeley, Derek F. Jackson Kimball, California State University, East Bay
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- Optical Magnetometry
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- 05 May 2013
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- 07 March 2013, pp 251-264
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Summary
Introduction
Shortly after the inception of atomic magnetometry, alkali-vapor magnetometers were being used to measure the Earth's magnetic field to unprecedented precision. During the same era, Bell and Bloom first demonstrated all-optical atomic magnetometry through synchronous optical pumping [1] (see Chapters 1 and 6). In this approach, optical-pumping light is frequency- or amplitude-modulated at harmonics of the Larmor frequency ωL to generate a precessing spin polarization within an alkali vapor at finite magnetic field [2, 3]. Although this technique received considerable attention from the atomic physics community for its applicability to optical pumping experiments, Earth's-field alkali-vapor atomic magnetometers continued to rely on radiofrequency (RF) field excitation for several decades (see Chapter 4). Upon the advent of diode lasers addressing alkali and metastable helium transitions, synchronously pumped magnetometers experienced a revival beginning in the late 1980s. In recent years, such magnetometers have found applications in nuclear magnetic resonance detection [4] (see also Chapter 14), quantum control experiments [5], and chip-scale devices intended for spacecraft use [6] (see also Chapters 7 and 15).
All-optical magnetometers possess several advantages over devices that employ RF coils. RF-driven magnetometers can suffer from cross-talk if two sensors are placed in close proximity, since the AC magnetic field driving resonance in one vapor cell can adversely affect the other. All-optical magnetometers are free from such interference. When operated in self-oscillating mode [7], RF-driven magnetometers require an added ±90° electronic phase shift in the feedback loop to counter the intrinsic phase shift between the RF field and the probe-beam modulation.
A Rapid Staining Method for Clinical Study of Cockroach Blood Cells1
- D. S. Sarkaria, Sergio Bettini, R. L. Patton
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- The Canadian Entomologist / Volume 83 / Issue 12 / December 1951
- Published online by Cambridge University Press:
- 31 May 2012, pp. 329-332
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In order to expedite the study of the effects of various biologically active chemicals upon the blood cells of insects a rapid clinical type method was needed that would allow preparations to be made with small (1 microliter or less) samples of blood which could be drawn without sacrificing the insect, and could be fixed and stained quickly for examination. A method meeting these requirements for the study of the blood cells of the American and German cockroaches has been developed.
Contributors
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- By Audrey N. Beck, John Berry, Edmond P. Bowers, Xenia Chryssochoou, Miles Corak, Radosveta Dimitrova, Andrew J. Fuligni, Eugene E. García, Cynthia Garcia Coll, Jonathan Israel Gershuny, Taveeshi Gupta, Donald J. Hernandez, Gabriel Horenczyk, Inga Jasinskaja-Lahti, Ciğdem Kağitçibaşi, Yoav Lavee, Jacqueline V. Lerner, Richard M. Lerner, Selva Lewin-Bizan, Karmela Liebkind, Tuuli Anna Mähönen, Amy Kerivan Marks, Ann S. Masten, Andrea Michel, Frosso Motti-Stefanidi, Brian Nolan, Andrea Patrico, Flannery Patton, Jean Phinney, Karen Robson, Abraham Sagi-Schwartz, David Lackland Sam, Rainer K. Silbereisen, Selcuk R. Sirin, Timothy M. Smeeding, Christiane Spiel, Dagmar Strohmeier, Gloria A. Suarez, Moshe Tatar, Eva H. Telzer, Marta Tienda, Peter F. Titzmann, Maykel Verkuyten, Coady Wing, Rui Yang
- Edited by Ann S. Masten, Karmela Liebkind, Donald J. Hernandez, Hunter College, City University of New York
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- Realizing the Potential of Immigrant Youth
- Published online:
- 05 November 2012
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- 21 May 2012, pp xiii-xviii
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Gas Flows in Galaxies: the Relative Importance of Mergers and Bars.
- Sara L. Ellison, David R. Patton, Preethi Nair, Luc Simard, J. Trevor Mendel, Alan W. McConnachie, Jillian M. Scudder
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- Journal:
- Proceedings of the International Astronomical Union / Volume 6 / Issue S277 / December 2010
- Published online by Cambridge University Press:
- 05 December 2011, pp. 178-181
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- December 2010
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Galaxy-galaxy interactions and large scale galaxy bars are usually considered as the two main mechanisms for driving gas to the centres of galaxies. By using large samples of galaxy pairs and visually classified bars from the Sloan Digital Sky Survey (SDSS), we compare the relative efficiency of gas inflows from these two processes. We use two indicators of gas inflow: star formation rate (SFR) and gas phase metallicity, which are both measured relative to control samples. Whereas the metallicity of galaxy pairs is suppressed relative to its control sample of isolated galaxies, galaxies with bars are metal-rich for their stellar mass by 0.06 dex over all stellar masses. The SFRs of both the close galaxy pairs and the barred galaxies are enhanced by ~60%, but in the bars the enhancement is only seen at stellar masses M∗ > 1010 M⊙. Taking into account the relative frequency of bars and pairs, we estimate that at least three times more central star formation is triggered by bars than by interactions.
Contributors
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- By Sonia Ancoli-Israel, Ragnar Asplund, Michel Billiard, Theresa M. Buckley, Rohit Budhiraja, Robert N. Butler, Daniel J. Buysse, Scott S. Campbell, Daniel P. Cardinali, Julie Carrier, Cynthia L. Comella, Jana R. Cooke, Pietro Cortelli, Agnès Demazieres, Glenna A. Dowling, Luigi Ferini-Strambi, Philip R. Gehrman, Nalaka Sudheera Gooneratne, David S. Hallegua, Patrick J. Hanly, David G. Harper, Orla P. Hornung, Magdolna Hornyak, Michal Karasek, Milton Kramer, Andrew D. Krystal, Malcolm H. Lader, Rachel Leproult, Kenneth L. Lichstein, Andrea H.S. Loewen, Rémy Luthringer, Laurin J. Mack, Evelyn Mai, Atul Malhotra, Jennifer L. Martin, Judy Mastick, Monique A.J. Mets, Andrew A. Monjan, Timothy H. Monk, Daniel Monti, Jaime M. Monti, Patricia J. Murphy, C. Ineke Neutel, Eric A. Nofzinger, Seithikurippu R. Pandi-Perumal, Scott B. Patton, Donald B. Penzien, Max H. Pittler, Giora Pillar, Marc J. Poulin, Louis J. Ptácek, Stuart F. Quan, Jeanetta C. Rains, Megan E. Ruiter, Bruce D. Rybarczyk, Colin M. Shapiro, Vijay Kumar Sharma, D. Warren Spence, Kai Spiegelhalder, Luc Staner, Stephanie A. Studenski, Nikola N. Trajanovic, Eve Van Cauter, Gregory S. Vander Wal, Joris C. Verster, Aleksandar Videnovic, Matthew P. Walker, Daniel J. Wallace, David K. Welsh, David P. White, Barbara Wider, Theresa B. Young, Stefano Zanigni
- Edited by S. R. Pandi-Perumal, Jaime M. Monti, Universidad de la República, Uruguay, Andrew A. Monjan, National Institute on Aging, Bethesda, Maryland
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- Principles and Practice of Geriatric Sleep Medicine
- Published online:
- 04 August 2010
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- 26 November 2009, pp ix-xii
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Predicting change with the RBANS in a community dwelling elderly sample
- KEVIN DUFF, MIKE R. SCHOENBERG, DOYLE PATTON, JAMES MOLD, JAMES G. SCOTT, RUSSELL L. ADAMS
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- Journal:
- Journal of the International Neuropsychological Society / Volume 10 / Issue 6 / October 2004
- Published online by Cambridge University Press:
- 01 October 2004, pp. 828-834
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Repeated neuropsychological assessments are common with older adults, and the determination of clinically significant change across time is an important issue. Regression-based prediction formulas have been utilized with other patient and healthy control samples to predict follow-up test performance based on initial performance and demographic variables. Comparisons between predicted and observed follow-up performances can assist clinicians in determining the significance of change in the individual patient. In the current study, multiple regression-based prediction equations for the 5 Indexes and Total Score of the RBANS were developed for a sample of 223 community dwelling older adults. These algorithms were then validated on a separate elderly sample (N = 222). Minimal differences were present between observed and predicted follow-up scores in the validation sample, suggesting that the prediction formulas are clinically useful for practitioners who assess older adults. A case example is presented that illustrates how the algorithms can be used clinically. (JINS, 2004, 10, 828–834.)
Having Your Cake and Eating It Too: A Procedure for Obtaining Plan View and Cross Section TEM Images from the Same Site
- R. B. Irwin, A. Anciso, P.J. Jones, C. Patton
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- Journal:
- Microscopy and Microanalysis / Volume 10 / Issue S02 / August 2004
- Published online by Cambridge University Press:
- 01 August 2004, pp. 1146-1147
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- August 2004
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Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.